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Play Music Now | Watch Music Videos | Genius All Access Sign Up Genius Subscribe Song by Song What’s New Categorize Genre Genres Podcasts Genres Service · Genius Radios · Genres.. Looks like news about Whiplash takes forever to reach you.Aberrant expression of anti-apoptotic Bcl-2 family proteins in osteosarcoma correlates with disease progression, metastasis and prognosis.
Osteosarcoma is a mesenchymal malignant tumor characterized by a high proliferation rate, production of osteoid matrix, and frequent metastasis to the lung. Tumor progression, metastasis, and prognosis of osteosarcoma are still poor and the molecular events underlying tumor progression remain unclear. Anti-apoptotic Bcl-2 family proteins, including Bcl-2 and Bcl-xL, are frequently expressed in tumor cells, which are usually associated with chemotherapeutic resistance. The purpose of this study was to investigate the correlation of Bcl-2 family proteins with tumor progression, prognosis, and clinical pathology of osteosarcoma. We detected the expression of Bcl-2 and Bcl-xL proteins in malignant and benign bones, and evaluated their relationship with clinical-pathological parameters in osteosarcoma. The results showed that the positive rates of Bcl-2 and Bcl-xL in osteosarcoma were significantly higher than those in non-neoplastic bones. The expression of Bcl-2 and Bcl-xL proteins in osteosarcoma was significantly correlated with larger tumors, local recurrence, distant metastasis, and shorter overall survival. The multivariate analysis identified the expression of Bcl-2 and Bcl-xL as an independent prognostic factor for survival in osteosarcoma. In conclusion, our study suggested that Bcl-2 and Bcl-xL may play an important role in the tumor progression of osteosarcoma, and that the altered expression of Bcl-2 and Bcl-xL might be a promising prognostic biomarker for osteosarcoma patients./*
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