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公開日:2023/01/15 / 最終更新日:2023/01/15
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comfast cf driver download, comfast cf driver download windows 7, comfast driver download windows 10, comfast cf driver windows .MicroRNA (miRNA) will be used to identify the markers of tumor progression and predict the therapeutic outcome in patients diagnosed with breast cancer. Current methodologies of biomarker discovery in breast cancer rely on mRNA expression analysis in primary tumor biopsies to distinguish between tumors of low- and high-risk. However, the lack of insight on the functional impact and prognostic potential of mRNA expression profiles at the level of the proteome hampers the refinement of therapeutic strategies. This proposal seeks to investigate the potential of miRNA biomarkers to discriminate between tumors of low- and high-risk for distant metastases, and to identify the prognostic potential of miRNAs in breast cancer. miRNA-binding sites will be identified in mRNA sequences from primary tumors and matched lymph node metastases, in order to establish a link between mRNA and miRNA expression, and to explore the potential prognostic significance of altered microRNA expression in tumor cells. The proposed study takes advantage of the data and clinical specimens available in the randomized MA.17 trial. The MA.17 trial was designed to evaluate the effect of treatment of newly diagnosed stage I-III breast cancer patients with anastrozole, tamoxifen or a combination of both. Patients were randomly assigned to receive one of the three treatment regimens, and tumors from approximately 600 patients are available for analyses. We hypothesize that the miRNA profiles of primary tumors and metastases will be useful as prognostic biomarkers, with complementary roles as biomarkers for distant metastases. The proposed work will improve our understanding of miRNA biomarkers, facilitating their translation to clinical settings. The results will provide clinical validation of the prognostic potential of miRNA and contribute to the study of the role of miRNA in breast cancer progression. This work is aligned with the missions of the Oncology Translational Network and the NCI.
Public Health Relevance
MicroRNA will be used to identify the markers of tumor progression and predict
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